Optogenetics: Applications in psychiatric research
نویسندگان
چکیده
منابع مشابه
Optogenetics: Applications in psychiatric research: Optogenetics for psychiatric research
Recently, optogenetic techniques have emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics results from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millise...
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In complex multicellular systems, such as the brain or the heart, the ability to selectively perturb and observe the response of individual components at the cellular level and with millisecond resolution in time, is essential for mechanistic understanding of function. Optogenetics uses genetic encoding of light sensitivity (by the expression of microbial opsins) to provide such capabilities fo...
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Psychiatric disorders disturb higher cognitive functions and severely compromise human health. However, the pathophysiological mechanisms underlying psychiatric disorders are very complex, and understanding these mechanisms remains a great challenge. Currently, many psychiatric disorders are hypothesized to reflect "faulty wiring" or aberrant connectivity in the brains. Imaging connectomics is ...
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Comprehension of the brain function can be helpful for therapy of neurodegenerative diseases. The brain consists of various types of neuron sets, which organize in three-dimensional complex networks and form neural circuits underlying different behaviors. The circuits act based on the patterns that encode the brain functions. Recognition of the neural patterns requires methods to manipulate the...
متن کاملOptogenetics and the circuit dynamics of psychiatric disease.
Optogenetics is a method for delivering millisecondprecision control (for activation or inhibition) to targeted cells using light within freely behaving mammals.1 The components of this method, as practiced today, involve (1) lasers and fiber optics for light delivery into the nervous system and (2) genes called microbial opsins, which encode light-activated proteins that regulate transmembrane...
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ژورنال
عنوان ژورنال: Psychiatry and Clinical Neurosciences
سال: 2017
ISSN: 1323-1316
DOI: 10.1111/pcn.12516